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USC-OGP 2-DE database
Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database
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Searching in 'USC-OGP 2-DE database' for entry
matching:
NDKA_HUMAN
USC-OGP 2-DE database
:
NDKA_HUMAN
NDKA_HUMAN
General information about the entry
View entry in simple text format
Entry name
NDKA_HUMAN
Primary accession number
P15531
integrated into USC-OGP 2-DE database on
January 17, 2017 (release 1)
2D Annotations were last modified on
January 17, 2017 (version 1)
General Annotations were last modified on
April 5, 2017 (version 2)
Name and origin of the protein
Description
RecName: Full=Nucleoside diphosphate kinase A; Short=NDK A; Short=NDP kinase A; EC=2.7.4.6; AltName: Full=Granzyme A-activated DNase; Short=GAAD; AltName: Full=Metastasis inhibition factor nm23; AltName: Full=NM23-H1; AltName: Full=Tumor metastatic process-associated protein;.
Gene name
Name=NME1
Synonyms=NDPKA, NM23
Annotated species
Homo sapiens (Human) [TaxID:
9606
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]
2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein
PLATELET_4-7
{PLATELET 4-7}
Homo sapiens (Human)
map experimental info
PLATELET_4-7
MAP LOCATIONS:
SPOT OGP-0573
:
pI=5.64; Mw=19276
UVEAL_MELANOMA_3-10
{UVEAL MELANOMA 3-10}
Homo sapiens (Human)
map experimental info
UVEAL_MELANOMA_3-10
MAP LOCATIONS:
SPOT OGP-1317
:
pI=5.84; Mw=19745
SPOT OGP-1320
:
pI=4.70; Mw=19395
Cross-references
UniProtKB/Swiss-Prot
P15531; NDKA_HUMAN.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
0.0
Entry name
NDKA_HUMAN
Primary accession number
P15531
Secondary accession number(s)
Q6FGK3 Q86XQ2 Q9UDJ6
Sequence was last modified on
April 1, 1990 (version 1)
Annotations were last modified on
March 15, 2017 (version 198)
Name and origin of the protein
Description
RecName: Full=Nucleoside diphosphate kinase A; Short=NDK A; Short=NDP kinase A; EC=2.7.4.6; AltName: Full=Granzyme A-activated DNase; Short=GAAD; AltName: Full=Metastasis inhibition factor nm23; AltName: Full=NM23-H1; AltName: Full=Tumor metastatic process-associated protein;
Gene name
Name=NME1
Synonyms=NDPKA, NM23
Encoded on
Name=NME1; Synonyms=NDPKA, NM23
Keywords
3D-structure
;
Alternative splicing
;
ATP-binding
;
Complete proteome
;
Cytoplasm
;
Differentiation
;
Direct protein sequencing
;
Endocytosis
;
Isopeptide bond
;
Kinase
;
Magnesium
;
Metal-binding
;
Neurogenesis
;
Nucleotide metabolism
;
Nucleotide-binding
;
Nucleus
;
Phosphoprotein
;
Polymorphism
;
Reference proteome
;
Transferase
;
Ubl conjugation
.
Copyright
Copyrighted by the UniProt Consortium, see
http://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
X17620; CAA35621.1
; ALT_INIT; mRNA
EMBL
X73066; CAA51527.1
; -; mRNA
EMBL
X75598; CAA53270.1
; -; Genomic_DNA
EMBL
AF487339; AAO85436.1
; -; mRNA
EMBL
AK291105; BAF83794.1
; -; mRNA
EMBL
CR542104; CAG46901.1
; -; mRNA
EMBL
CR542115; CAG46912.1
; -; mRNA
EMBL
AC005839; -
; NOT_ANNOTATED_CDS; Genomic_DNA
EMBL
CH471109; EAW94568.1
; -; Genomic_DNA
EMBL
BC000293; AAH00293.1
; -; mRNA
EMBL
BC018994; AAH18994.1
; -; mRNA
CCDS
CCDS11578.1; -. [P15531-2]
; .
CCDS
CCDS11579.1; -. [P15531-1]
; .
PIR
A33386; A33386
; .
RefSeq
NP_000260.1; NM_000269.2. [P15531-1]
; .
RefSeq
NP_937818.1; NM_198175.1. [P15531-2]
; .
UniGene
Hs.463456; -
; .
PDB
1JXV; X-ray
; 2.20 A; A/B/C/D/E/F=1-152
PDB
1UCN; X-ray
; 2.00 A; A/B/C=1-152
PDB
2HVD; X-ray
; 2.15 A; A/B/C=1-152
PDB
2HVE; X-ray
; 2.40 A; A/B/C=1-152
PDB
3L7U; X-ray
; 2.10 A; A/B/C=1-152
PDB
4ENO; X-ray
; 2.80 A; A/B=1-152
PDBsum
1JXV; -
; .
PDBsum
1UCN; -
; .
PDBsum
2HVD; -
; .
PDBsum
2HVE; -
; .
PDBsum
3L7U; -
; .
PDBsum
4ENO; -
; .
ProteinModelPortal
P15531; -
; .
SMR
P15531; -
; .
BioGrid
110894; 58
; .
DIP
DIP-39164N; -
; .
IntAct
P15531; 29
; .
MINT
MINT-221462; -
; .
STRING
9606.ENSP00000013034; -
; .
ChEMBL
CHEMBL2159; -
; .
DrugBank
DB03491; 2'-Deoxyguanosine-5'-Diphosphate
; .
DrugBank
DB02181; 2'-Deoxyguanosine-5'-Triphosphate
; .
DrugBank
DB04542; 3'-Azido-3'-Deoxythymidine-5'-Diphosphate
; .
DrugBank
DB04366; 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate
; .
DrugBank
DB00718; Adefovir Dipivoxil
; .
DrugBank
DB02607; Adenosine Phosphonoacetic Acid
; .
DrugBank
DB04068; Fudp
; .
DrugBank
DB04315; Guanosine-5'-Diphosphate
; .
DrugBank
DB00709; Lamivudine
; .
DrugBank
DB02345; Selenocysteine
; .
DrugBank
DB00300; Tenofovir
; .
DrugBank
DB03103; Thymidine-5'- Diphosphate
; .
iPTMnet
P15531; -
; .
PhosphoSitePlus
P15531; -
; .
SwissPalm
P15531; -
; .
BioMuta
NME1; -
; .
DMDM
127981; -
; .
DOSAC-COBS-2DPAGE
P15531; -
; .
OGP
P15531; -
; .
EPD
P15531; -
; .
PaxDb
P15531; -
; .
PeptideAtlas
P15531; -
; .
PRIDE
P15531; -
; .
TopDownProteomics
P15531-1; -. [P15531-1]
; .
DNASU
4830; -
; .
Ensembl
ENST00000013034; ENSP00000013034
; ENSG00000239672. [P15531-2]; .
Ensembl
ENST00000336097; ENSP00000337060
; ENSG00000239672. [P15531-2]; .
Ensembl
ENST00000393196; ENSP00000376892
; ENSG00000239672. [P15531-1]; .
GeneID
4830; -
; .
KEGG
hsa:4830; -
; .
UCSC
uc002ith.3; human. [P15531-1]
; .
CTD
4830; -
; .
DisGeNET
4830; -
; .
GeneCards
NME1; -
; .
HGNC
HGNC:7849; NME1
; .
HPA
CAB040571; -
; .
HPA
HPA008467; -
; .
HPA
HPA041113; -
; .
MalaCards
NME1; -
; .
MIM
156490; gene
; .
neXtProt
NX_P15531; -
; .
OpenTargets
ENSG00000239672; -
; .
PharmGKB
PA249; -
; .
eggNOG
KOG0888; Eukaryota
; .
eggNOG
COG0105; LUCA
; .
GeneTree
ENSGT00760000119146; -
; .
HOGENOM
HOG000224564; -
; .
HOVERGEN
HBG000423; -
; .
InParanoid
P15531; -
; .
KO
K00940; -
; .
OMA
VERFFME; -
; .
OrthoDB
EOG091G0PLD; -
; .
PhylomeDB
P15531; -
; .
TreeFam
TF106373; -
; .
BioCyc
MetaCyc:ENSG00000011052-MONOMER; -
; .
BRENDA
2.7.4.6; 2681
; .
Reactome
R-HSA-499943; Synthesis and interconversion of nucleotide di- and triphosphates
; .
SIGNOR
P15531; -
; .
ChiTaRS
NME1; human
; .
EvolutionaryTrace
P15531; -
; .
GeneWiki
NME1; -
; .
GenomeRNAi
4830; -
; .
PRO
PR:P15531; -
; .
Proteomes
UP000005640; Chromosome 17
; .
Bgee
ENSG00000239672; -
; .
CleanEx
HS_NME1; -
; .
ExpressionAtlas
P15531; baseline and differential
; .
Genevisible
P15531; HS
; .
GO
GO:0005813; C:centrosome
; IEA:Ensembl; .
GO
GO:0005737; C:cytoplasm
; TAS:UniProtKB; .
GO
GO:0005829; C:cytosol
; IDA:UniProtKB; .
GO
GO:0070062; C:extracellular exosome
; IDA:UniProtKB; .
GO
GO:0005882; C:intermediate filament
; IEA:Ensembl; .
GO
GO:0016020; C:membrane
; IDA:UniProtKB; .
GO
GO:0005741; C:mitochondrial outer membrane
; IEA:Ensembl; .
GO
GO:0043209; C:myelin sheath
; IEA:Ensembl; .
GO
GO:0005634; C:nucleus
; IDA:UniProtKB; .
GO
GO:0048471; C:perinuclear region of cytoplasm
; IEA:Ensembl; .
GO
GO:0032587; C:ruffle membrane
; IDA:UniProtKB; .
GO
GO:0005524; F:ATP binding
; IDA:UniProtKB; .
GO
GO:0004536; F:deoxyribonuclease activity
; IDA:UniProtKB; .
GO
GO:0005525; F:GTP binding
; IDA:UniProtKB; .
GO
GO:0042802; F:identical protein binding
; IPI:IntAct; .
GO
GO:0000287; F:magnesium ion binding
; IDA:UniProtKB; .
GO
GO:0004550; F:nucleoside diphosphate kinase activity
; IDA:UniProtKB; .
GO
GO:0043024; F:ribosomal small subunit binding
; IPI:UniProtKB; .
GO
GO:0003723; F:RNA binding
; IDA:UniProtKB; .
GO
GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding
; IEA:Ensembl; .
GO
GO:0003697; F:single-stranded DNA binding
; IEA:Ensembl; .
GO
GO:0035690; P:cellular response to drug
; IEA:Ensembl; .
GO
GO:0071398; P:cellular response to fatty acid
; IEA:Ensembl; .
GO
GO:0071333; P:cellular response to glucose stimulus
; IEA:Ensembl; .
GO
GO:0006241; P:CTP biosynthetic process
; IEA:InterPro; .
GO
GO:0006897; P:endocytosis
; IEA:UniProtKB-KW; .
GO
GO:0006183; P:GTP biosynthetic process
; IEA:InterPro; .
GO
GO:0021766; P:hippocampus development
; IEA:Ensembl; .
GO
GO:0007595; P:lactation
; IEA:Ensembl; .
GO
GO:0008285; P:negative regulation of cell proliferation
; TAS:UniProtKB; .
GO
GO:0010629; P:negative regulation of gene expression
; IEA:Ensembl; .
GO
GO:0002762; P:negative regulation of myeloid leukocyte differentiation
; IEA:Ensembl; .
GO
GO:0015949; P:nucleobase-containing small molecule interconversion
; TAS:Reactome; .
GO
GO:0043388; P:positive regulation of DNA binding
; IDA:UniProtKB; .
GO
GO:0050679; P:positive regulation of epithelial cell proliferation
; IMP:HGNC; .
GO
GO:0010976; P:positive regulation of neuron projection development
; IEA:Ensembl; .
GO
GO:0042981; P:regulation of apoptotic process
; TAS:UniProtKB; .
GO
GO:0014075; P:response to amine
; IEA:Ensembl; .
GO
GO:0051591; P:response to cAMP
; IEA:Ensembl; .
GO
GO:0033574; P:response to testosterone
; IEA:Ensembl; .
GO
GO:0006228; P:UTP biosynthetic process
; IEA:InterPro; .
HAMAP
MF_00451; NDP_kinase
; 1; .
InterPro
IPR001564; Nucleoside_diP_kinase
; .
InterPro
IPR023005; Nucleoside_diP_kinase_AS
; .
Pfam
PF00334; NDK
; 1; .
PRINTS
PR01243; NUCDPKINASE
; .
SMART
SM00562; NDK
; 1; .
PROSITE
PS00469; NDP_KINASES
; 1; .
Gateways to other related servers
The World-2DPAGE Constellation
- Entry point to the world-wide 2-DPAGE resources.
World-2DPAGE Repository
- A public repository for gel-based proteomics data linked to protein identification published in the literature.
World-2DPAGE Portal
- A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
SWISS-2DPAGE
- The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
ExPASy
- The resources web server of the
Swiss Institute of Bioinformatics
Database constructed and maintained by
Angel Garcia
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
ExPASy web server
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